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Clinical Trials Using Hydroxychloroquine - National Cancer ...
www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/hydroxychloroquine
Hydroxychloroquine (an autophagy inhibitor) enhances the activity of standard chemotherapy on cancer cells and prevent them to utilize energy to grow ...
Hydroxychloroquine and risk of development of cancers: a ...
pubmed.ncbi.nlm.nih.gov/30154660/
Background: Hydroxychloroquine (HCQ), one of the disease-modifying antirheumatic drugs, may lead to an inhibition of autophagy. Autophagy, an ...
Chloroquine and hydroxychloroquine for cancer therapy
pubmed.ncbi.nlm.nih.gov/27308318/
Chloroquine and hydroxychloroquine for cancer therapy Mol Cell Oncol. 2014 Jul 15;1(1):e29911. doi: 10.4161/mco.29911. eCollection 2014. Authors ...
Hydroxychloroquine induced lung cancer suppression by ...
pubmed.ncbi.nlm.nih.gov/30373678/
Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages J ...
Hydroxychloroquine for the Treatment of Recurrent ...
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2019-08359
This phase II trial studies how well hydroxychloroquine works in treating patients with prostate cancer that has come back (recurrent) and has spread ...
Research progress of hydroxychloroquine and autophagy ...
pubmed.ncbi.nlm.nih.gov/27889812/
Purpose: Hydroxychloroquine (HCQ), the analog of chloroquine, augments the effect of chemotherapies and radiotherapy on various tumors identified in ...
Phase Ib/II study of hydroxychloroquine in combination ...
pubmed.ncbi.nlm.nih.gov/31521049/
Addition of hydroxychloroquine is safe and tolerable with a modest improvement in clinical responses compared to prior studies. Autophagy inhibition ...
Binimetinib and Hydroxychloroquine in Treating Patients ...
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2019-04991
Hydroxychloroquine may prevent autophagy, a normal process in which a cell destroys proteins and other substances which may lead to cell death ...
Hydroxychloroquine, Palbociclib, and Letrozole before ...
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2018-01050
This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with palbociclib and letrozole before surgery ...
Sorafenib Tosylate and Hydroxychloroquine ... - cancer.gov
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2017-00157
This phase II trial studies how well sorafenib tosylate and hydroxychloroquine sulfate work in treating patients with liver cancer that has spread to ...
Chloroquine and hydroxychloroquine inhibit bladder cancer ...
pubmed.ncbi.nlm.nih.gov/28433067/
Chloroquine (CQ) and hydroxychloroquine (HCQ), two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we ...
Effect of hydroxychloroquine on COVID-19 prevention in ...
pubmed.ncbi.nlm.nih.gov/32586363/
Objectives: In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer ...
Hydroxychloroquine: A Physiologically-Based ...
pubmed.ncbi.nlm.nih.gov/29438998/
Hydroxychloroquine (HCQ) is a lysosomotropic autophagy inhibitor being used in over 50 clinical trials either alone or in combination with ...
Hydroxychloroquine inhibits autophagy to potentiate ...
pubmed.ncbi.nlm.nih.gov/24928945/
We have explored the ability of hydroxychloroquine (HCQ), which inhibits autophagy, to affect antiestrogen responsiveness. Experimental design ...
Hydroxychloroquine Sulfate with TACE in Treating Patients ...
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2014-00398
Hydroxychloroquine sulfate may help TACE work better by making tumor cells more sensitive to the drugs delivered via TACE. The TACE technique kills ...
Effect of Gemcitabine and nab-Paclitaxel With or Without ...
pubmed.ncbi.nlm.nih.gov/31120501/
Hydroxychloroquine sulfate (HCQ) is an inhibitor of autophagy that inhibits the fusion of the autophagosome to the lysosome. Objective: To determine ...
Hitting an Elusive Target in Pancreatic Cancer - National ...
www.cancer.gov/news-events/cancer-currents-blog/2019/pancreatic-cancer-targeting-kras-indirectly
In compliance with ethical guidelines, Dr. Kinsey offered the patient compassionate use and off-label treatment with trametinib and hydroxychloroquine ...
A Randomized Phase II Preoperative Study of Autophagy ...
pubmed.ncbi.nlm.nih.gov/32156749/
The addition of hydroxychloroquine to preoperative gemcitabine and nab-paclitaxel chemotherapy in patients with resectable pancreatic adenocarcinoma ...
Dabrafenib, Trametinib and Hydroxychloroquine in Treating ...
www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2015-00364
This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with dabrafenib and trametinib and to see how ...
Hydroxychloroquine in the treatment of outpatients with ...
pubmed.ncbi.nlm.nih.gov/33446136/
Background: Hydroxychloroquine has not been associated with improved survival among hospitalized COVID-19 patients in the majority of observational ...